SCHEMBL15947375

SCHEMBL15947375

CNCc1ccc(C(=O)NCCOCCOC)cc1

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 3/20 0.56
ALDH1A1 P00352 2/20 0.54
HPGD P15428 6/20 0.51
NAMPT P43490 1/20 0.49
KMT2A Q03164 3/20 0.48
CA2 P00918 2/20 0.48
NPC1 O15118 6/20 0.46
RAB9A P51151 3/20 0.46
HDAC1 Q13547 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
HSP90AA1 P07900 1/20 0.44
KDM4E B2RXH2 1/20 0.44
MEN1 O00255 1/20 0.44
EPHX2 P34913 1/20 0.44
NR1H4 Q96RI1 1/20 0.44
L3MBTL1 Q9Y468 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15947379 0.89 SMN1; SMN2 (0.53) SMN1; SMN2ALDH1A1HPGDNAMPTKMT2A
SCHEMBL15947373 0.88 SMN1; SMN2 (0.56) SMN1; SMN2ALDH1A1HPGDNAMPTKMT2A
SCHEMBL21440839 0.88 SMN1; SMN2 (0.52) SMN1; SMN2ALDH1A1HPGDNAMPTKMT2A
SCHEMBL12373077 0.87 HPGD (0.56) SMN1; SMN2ALDH1A1HPGDNAMPTKMT2A
SCHEMBL15947378 0.85 SMN1; SMN2 (0.51) SMN1; SMN2HPGDNPC1RAB9AHDAC1
SCHEMBL8404694 0.85 SMN1; SMN2 (0.59) SMN1; SMN2ALDH1A1HPGDKMT2ACA2
SCHEMBL14853582 0.85 SMN1; SMN2 (0.52) SMN1; SMN2ALDH1A1HPGDNAMPTKMT2A
SCHEMBL24518572 0.84 SMN1; SMN2 (0.58) SMN1; SMN2ALDH1A1HPGDKMT2ACA2
SCHEMBL8404700 0.84 SMN1; SMN2 (0.58) SMN1; SMN2ALDH1A1HPGDKMT2ACA2
SCHEMBL23509565 0.82 NPC1 (0.65) SMN1; SMN2ALDH1A1HPGDKMT2ACA2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20140227780-A1 METHOD FOR PRODUCING MEGAKARYOCYTES AND/OR PLATELETS FROM PLURIPOTENT STEM CELLS NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2014-08-14 US disclosed