Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 9/20 | 0.61 |
| ▸ | MEN1 | O00255 | 7/20 | 0.61 |
| ▸ | STAT3 | P40763 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 5/20 | 0.48 |
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.48 |
| ▸ | RGS12 | O14924 | 2/20 | 0.48 |
| ▸ | GMNN | O75496 | 2/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15947782 | 1.00 | KMT2A (0.61) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| Mol-4239 SCHEMBL1316581 | 0.88 | STAT3 (0.77) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| SCHEMBL841260 | 0.88 | KMT2A (0.60) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| SCHEMBL1573453 | 0.88 | KMT2A (0.60) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| SCHEMBL841782 | 0.88 | KMT2A (0.60) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| SCHEMBL841259 | 0.88 | KMT2A (0.60) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| Mol-4239 SCHEMBL862248 | 0.88 | STAT3 (0.77) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| Mol-4239 SCHEMBL1318844 | 0.88 | STAT3 (0.77) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| SCHEMBL841781 | 0.88 | KMT2A (0.60) | KMT2AMEN1STAT3ALDH1A1KDM4E | |
| Mol-4239 SCHEMBL29818004 | 0.88 | STAT3 (0.77) | KMT2AMEN1STAT3ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140228414-A1 | NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STATS) | BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (US) | 2014-08-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140228414-A1 | NOVEL INHIBITORS OF PROLIFERATION AND ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STATS) | STAT5A, STAT3, STAT5B | KMT2A 1746/4885MEN1 4004/4885STAT3 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.