Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 8/20 | 0.41 |
| ▸ | PDE4D | Q08499 | 6/20 | 0.40 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.33 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12888425 | 0.91 | PDE4B (0.43) | PDE4BPDE4DCYP2A6ALDH1A1RAB9A | |
| SCHEMBL15660694 | 0.81 | PDE4B (0.54) | PDE4BPDE4DALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL12888431 | 0.76 | PDE4B (0.48) | PDE4BPDE4DCYP2A6LMNAALDH1A1 | |
| SCHEMBL12888482 | 0.76 | PDE4B (0.43) | PDE4BPDE4DCYP2A6LMNAALDH1A1 | |
| SCHEMBL7471930 | 0.74 | CYP2A6 (0.39) | PDE4BPDE4DCYP2A6ALDH1A1RAB9A | |
| SCHEMBL15659833 | 0.73 | PDE4B (0.51) | PDE4BPDE4DCYP2A6ALDH1A1RAB9A | |
| SCHEMBL26674123 | 0.71 | PTGS1 (0.39) | PDE4BCYP2A6ALDH1A1RAB9APTGS1 | |
| SCHEMBL7472143 | 0.71 | CYP2A6 (0.41) | PDE4BPDE4DCYP2A6LMNAALDH1A1 | |
| SCHEMBL16446540 | 0.69 | PDE4B (0.35) | PDE4BPDE4DCYP2A6ALDH1A1RAB9A | |
| SCHEMBL7472147 | 0.69 | CYP2A6 (0.41) | PDE4BPDE4DCYP2A6LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014066659-A9 | HETEROARYL INHIBITORS OF PDE4 | TETRA DISCOVERY PARTNERS, LLC. (US) | 2015-02-12 | — | — | WO | disclosed |