SCHEMBL15948018

SCHEMBL15948018

CCc1cc(Nc2ccc(CCN(C)C)cc2)nc(-c2cccc(Cl)c2)n1

nearest known ligand 0.77

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PDE4B Q07343 17/20 0.77
PDE4D Q08499 6/20 0.47
CYP3A4 P08684 2/20 0.47
CYP2C19 P33261 1/20 0.47
TAAR1 Q96RJ0 1/20 0.43
ABCB1 P08183 1/20 0.42
ABCC1 P33527 1/20 0.42
ABCG2 Q9UNQ0 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL16669462 0.99 PDE4B (0.76) PDE4BPDE4DCYP3A4CYP2C19TAAR1
SCHEMBL15658387 0.87 PDE4B (1.00) PDE4BPDE4DCYP3A4CYP2C19
SCHEMBL15660397 0.80 PDE4B (1.00) PDE4BPDE4DCYP3A4CYP2C19
SCHEMBL15659003 0.80 PDE4B (0.68) PDE4BPDE4DCYP3A4CYP2C19
SCHEMBL15660582 0.79 PDE4B (0.67) PDE4BPDE4DCYP3A4CYP2C19
SCHEMBL15660783 0.78 PDE4B (0.77) PDE4BPDE4DCYP3A4CYP2C19
SCHEMBL19413795 0.78 PDE4B (0.72) PDE4BPDE4DCYP3A4CYP2C19ABCB1
SCHEMBL19413796 0.77 PDE4B (0.71) PDE4BPDE4DCYP3A4CYP2C19ABCB1
SCHEMBL15660924 0.77 PDE4B (0.71) PDE4BPDE4DCYP3A4CYP2C19ABCB1
SCHEMBL15657618 0.76 PDE4B (0.64) PDE4BPDE4DCYP3A4CYP2C19ABCB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20230348501-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2023-11-02 US disclosed
US-11767334-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners, LLC (US) 2023-09-26 US disclosed
US-20230024240-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2023-01-26 US disclosed
EP-3842420-B1 HETEROARYL INHIBITORS OF PDE4 TETRA DISCOVERY PARTNERS LLC (US) 2022-12-07 EP disclosed
EP-3842420-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners LLC (US) 2021-06-30 EP disclosed
US-20200354384-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2020-11-12 US disclosed
US-10626129-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners, LLC (US) 2020-04-21 US disclosed
US-20190270759-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2019-09-05 US disclosed
US-10364258-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners, LLC (US) 2019-07-30 US disclosed
US-20190055269-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2019-02-21 US disclosed
US-20170342094-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2017-11-30 US disclosed
US-9777024-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners, LLC (US) 2017-10-03 US disclosed
US-20160137672-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2016-05-19 US disclosed
US-9221843-B2 Heteroaryl inhibitors of PDE4 Tetra Discovery Partners, LLC (US) 2015-12-29 US disclosed
CN-104768932-A Heteroaryl inhibitors of PDE4 TETRA DISCOVERY PARTNERS LLC 2015-07-08 CN disclosed
US-20150119362-A1 HETEROARYL INHIBITORS OF PDE4 Tetra Discovery Partners, LLC 2015-04-30 US disclosed
WO-2014066659-A9 HETEROARYL INHIBITORS OF PDE4 TETRA DISCOVERY PARTNERS, LLC. (US) 2015-02-12 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (11 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20190270759-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-20200354384-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-20230024240-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-20150119362-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 209/4885
US-20190055269-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-20230348501-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-20170342094-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-11767334-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-10626129-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-10364258-B2 Heteroaryl inhibitors of PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 248/4885
US-20160137672-A1 HETEROARYL INHIBITORS OF PDE4 PDE4A, PDE4B, PDE4C PDE4B 2/4885PDE4D 9/4885CYP3A4 209/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.