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Sugi Predict / Compounds / SCHEMBL15958393

SCHEMBL15958393

SCHEMBL15958393

Cc1cc(S(=O)(=O)Nc2nc(C(F)(F)F)nc3c2CCN(C2CCN(Cc4ccccc4-c4ccc(Cl)cc4)CC2)C3)ccc1N[C@H](CCN(C)C)CSc1ccccc1

nearest known ligand 0.89

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
▸ BCL2 P10415 18/20 0.89
▸ BCL2L1 Q07817 13/20 0.89
▸ BCL2L2 Q92843 3/20 0.56
▸ BAD Q92934 2/20 0.49
▸ MDM4 O15151 1/20 0.49
▸ BCL2L11 O43521 1/20 0.49
▸ TP53 P04637 1/20 0.49
▸ BID P55957 1/20 0.49
▸ BAX Q07812 1/20 0.49
▸ MCL1 Q07820 1/20 0.49
▸ ASPH Q12797 1/20 0.49
▸ BECN1 Q14457 1/20 0.49
▸ BAK1 Q16611 1/20 0.49
▸ BBC3 Q9BXH1 1/20 0.49

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9951702 0.94 BCL2 (0.92) BCL2BCL2L1BCL2L2BADMDM4
SCHEMBL9951660 0.94 BCL2 (1.00) BCL2BCL2L1BCL2L2
SCHEMBL9951655 0.94 BCL2 (1.00) BCL2BCL2L1BCL2L2
SCHEMBL9951825 0.93 BCL2 (0.85) BCL2BCL2L1BCL2L2BADMDM4
SCHEMBL9951816 0.93 BCL2 (0.85) BCL2BCL2L1BCL2L2BADMDM4
SCHEMBL9951357 0.89 BCL2 (1.00) BCL2BCL2L1BCL2L2
SCHEMBL9951352 0.89 BCL2 (1.00) BCL2BCL2L1BCL2L2
SCHEMBL9952191 0.88 BCL2 (0.89) BCL2BCL2L1BCL2L2
SCHEMBL9951713 0.88 BCL2 (0.89) BCL2BCL2L1BCL2L2
SCHEMBL9952181 0.88 BCL2 (0.89) BCL2BCL2L1BCL2L2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809352-B2 Sulfonamides as inhibitors of Bcl-2 family proteins for the treatments of cancer NOVARTIS AG (CH) 2014-08-19 — — US disclosed
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