SCHEMBL15958748

SCHEMBL15958748

NC(=O)c1ncccc1OC[C@@H]1CCCN1C(=O)[C@H]1CC[C@@H](CF)CC1

nearest known ligand 0.40

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
CHRNB4 P30926 4/20 0.40
CHRNA3 P32297 4/20 0.40
CHRNB1 P11230 1/20 0.40
CHRNB2 P17787 1/20 0.40
CHRNA4 P43681 1/20 0.40
CHRNB3 Q05901 1/20 0.40
ABL1 P00519 1/20 0.37
RIN1 Q13671 1/20 0.37
HCRTR2 O43614 2/20 0.36
SMO Q99835 1/20 0.36
DPP4 P27487 1/20 0.36
SLC18A3 Q16572 1/20 0.35
HTR1A P08908 1/20 0.35
IRAK4 Q9NWZ3 1/20 0.35
SCD O00767 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15958745 1.00 CHRNB4 (0.40) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL9103292 0.89 CHRNB4 (0.43) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL9103284 0.89 CHRNB4 (0.43) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL1240455 0.88 CHRNB4 (0.39) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL1240459 0.88 CHRNB4 (0.39) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL1238397 0.88 CHRNB4 (0.39) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL1238403 0.88 CHRNB4 (0.39) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL1238400 0.88 CHRNB4 (0.39) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL1241521 0.88 CHRNB4 (0.39) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4
SCHEMBL9105066 0.86 CHRNB4 (0.40) CHRNB4CHRNA3CHRNB1CHRNB2CHRNA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8809380-B2 Picolinamide derivatives as TTX-S blockers RAQUALIA PHARMA INC. (JP) 2014-08-19 US disclosed