Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPBAR1 | Q8TDU6 | 6/20 | 0.40 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.38 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 3/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.32 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.32 |
| ▸ | CTSA | P10619 | 1/20 | 0.32 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL362259 | 0.89 | GPBAR1 (0.50) | GPBAR1NR3C2GAAMAPTCYP19A1 | |
| SCHEMBL362261 | 0.89 | GPBAR1 (0.50) | GPBAR1NR3C2GAAMAPTCYP19A1 | |
| SCHEMBL363993 | 0.89 | GPBAR1 (0.50) | GPBAR1NR3C2GAAMAPTCYP19A1 | |
| SCHEMBL362260 | 0.89 | GPBAR1 (0.50) | GPBAR1NR3C2GAAMAPTCYP19A1 | |
| SCHEMBL1389694 | 0.84 | GPBAR1 (0.60) | GPBAR1NR3C2GAAMAPTCTSA | |
| SCHEMBL1389695 | 0.84 | GPBAR1 (0.60) | GPBAR1NR3C2GAAMAPTCTSA | |
| SCHEMBL364346 | 0.84 | GPBAR1 (0.60) | GPBAR1NR3C2GAAMAPTCTSA | |
| SCHEMBL363855 | 0.84 | GPBAR1 (0.60) | GPBAR1NR3C2GAAMAPTCTSA | |
| SCHEMBL1389692 | 0.84 | GPBAR1 (0.60) | GPBAR1NR3C2GAAMAPTCTSA | |
| SCHEMBL15949123 | 0.81 | GPBAR1 (0.46) | GPBAR1NR3C2MAPTCYP19A1CTSA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2593426-B1 | 1-HYDROXYIMINO-3-PHENYL-PROPANES | HOFFMANN LA ROCHE (CH) | 2014-08-20 | — | — | EP | disclosed |