Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WEE1 | P30291 | 20/20 | 0.89 |
| ▸ | PLK1 | P53350 | 2/20 | 0.89 |
| ▸ | PKMYT1 | Q99640 | 2/20 | 0.89 |
| ▸ | GAK | O14976 | 1/20 | 0.89 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.89 |
| ▸ | JAK2 | O60674 | 1/20 | 0.89 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.89 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.89 |
| ▸ | PAK4 | O96013 | 1/20 | 0.89 |
| ▸ | ABL1 | P00519 | 1/20 | 0.89 |
| ▸ | LCK | P06239 | 1/20 | 0.89 |
| ▸ | FYN | P06241 | 1/20 | 0.89 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.89 |
| ▸ | WEE2 | P0C1S8 | 1/20 | 0.89 |
| ▸ | BCR | P11274 | 1/20 | 0.89 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.89 |
| ▸ | SYK | P43405 | 1/20 | 0.89 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.89 |
| ▸ | NEK2 | P51955 | 1/20 | 0.89 |
| ▸ | NEK3 | P51956 | 1/20 | 0.89 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adavosertib SCHEMBL30559444 | 0.94 | WEE1 (1.00) | WEE1PLK1PKMYT1GAKEPHB6 | |
| Adavosertib SCHEMBL1504444 | 0.94 | WEE1 (1.00) | WEE1PLK1PKMYT1GAKEPHB6 | |
| Adavosertib SCHEMBL29381006 | 0.94 | WEE1 (1.00) | WEE1PLK1PKMYT1GAKEPHB6 | |
| Adavosertib SCHEMBL1504998 | 0.93 | WEE1 (0.98) | WEE1PLK1PKMYT1GAKEPHB6 | |
| Adavosertib SCHEMBL1504996 | 0.93 | WEE1 (0.98) | WEE1PLK1PKMYT1GAKEPHB6 | |
| SCHEMBL1813967 | 0.93 | WEE1 (0.89) | WEE1PLK1PKMYT1GAKEPHB6 | |
| SCHEMBL26799813 | 0.93 | WEE1 (0.89) | WEE1PLK1PKMYT1GAKEPHB6 | |
| SCHEMBL25890930 | 0.92 | WEE1 (0.96) | WEE1PLK1PKMYT1GAKEPHB6 | |
| SCHEMBL1813347 | 0.92 | WEE1 (0.88) | WEE1PLK1PKMYT1GAKEPHB6 | |
| SCHEMBL1815951 | 0.91 | WEE1 (0.94) | WEE1PLK1PKMYT1GAKEPHB6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2477628-B1 | PREPARATION OF CRYSTALLINE HEMIHYDRATE FORMS OF DIHYDROPYRAZOLOPYRIMIDINONE | MERCK SHARP & DOHME (US) | 2014-08-20 | — | — | EP | disclosed |