Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR2 | P34972 | 11/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.32 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.32 |
| ▸ | CHRM1 | P11229 | 3/20 | 0.32 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.32 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14721762 | 1.00 | CNR2 (0.35) | CNR2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL14721759 | 1.00 | CNR2 (0.35) | CNR2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| Formic Acid SCHEMBL15878533 | 0.97 | CNR2 (0.34) | CNR2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL14734016 | 0.90 | CNR2 (0.35) | CNR2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL15881951 | 0.90 | CNR2 (0.35) | CNR2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL14727931 | 0.90 | CNR2 (0.35) | CNR2CYP3A4CYP2C9CYP2D6CYP2C19 | |
| SCHEMBL12497911 | 0.87 | TTK (0.34) | NPC1RAB9ACA1CA2 | |
| SCHEMBL2369205 | 0.87 | TTK (0.34) | NPC1RAB9ACA1CA2 | |
| SCHEMBL8515408 | 0.87 | TTK (0.34) | NPC1RAB9ACA1CA2 | |
| SCHEMBL740369 | 0.87 | CA1 (0.34) | CYP3A4ALDH1A1CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10710991-B2 | Process for the preparation of thietane derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2020-07-14 | — | — | US | disclosed |
| US-20190315728-A1 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2019-10-17 | — | — | US | disclosed |
| US-10266524-B2 | Process for the preparation of thietane derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2019-04-23 | — | — | US | disclosed |
| US-20170247361-A1 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-31 | — | — | US | disclosed |
| US-20170247361-A1 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2017-08-31 | — | — | US | disclosed |
| US-9682949-B2 | Process for the preparation of thietane derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2017-06-20 | — | — | US | disclosed |
| US-9682949-B2 | Process for the preparation of thietane derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2017-06-20 | — | — | US | disclosed |
| US-9204648-B2 | Process for the preparation of thietane derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-08 | — | — | US | disclosed |
| US-9204648-B2 | Process for the preparation of thietane derivatives | SYNGENTA PARTICIPATIONS AG (CH) | 2015-12-08 | — | — | US | disclosed |
| US-20140235869-A1 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-21 | — | — | US | disclosed |
| US-20140235869-A1 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES | SYNGENTA PARTICIPATIONS AG (CH) | 2014-08-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170247361-A1 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES | CYP4B1, CYP1B1, CYP1A1 | CNR2 1381/4885CYP3A4 4/4885CYP2C9 13/4885 |
| US-20140235869-A1 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES | CYP4B1, CYP1B1, CYP1A1 | CNR2 1504/4885CYP3A4 4/4885CYP2C9 13/4885 |
| US-10710991-B2 | Process for the preparation of thietane derivatives | CYP4B1, CYP1B1, CYP1A1 | CNR2 1381/4885CYP3A4 4/4885CYP2C9 13/4885 |
| US-20190315728-A1 | PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES | CYP4B1, CYP1B1, CYP1A1 | CNR2 1381/4885CYP3A4 4/4885CYP2C9 13/4885 |
| US-10266524-B2 | Process for the preparation of thietane derivatives | CYP4B1, CYP1B1, CYP1A1 | CNR2 1381/4885CYP3A4 4/4885CYP2C9 13/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.