Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 1.00 |
| ▸ | APP | P05067 | 2/20 | 1.00 |
| ▸ | CTSD | P07339 | 2/20 | 0.79 |
| ▸ | BACE2 | Q9Y5Z0 | 2/20 | 0.79 |
| ▸ | REN | P00797 | 1/20 | 0.72 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15966200 | 0.96 | BACE1 (1.00) | BACE1APPCTSDBACE2REN | |
| SCHEMBL23911787 | 0.95 | BACE1 (1.00) | BACE1APPCTSDBACE2REN | |
| SCHEMBL4306299 | 0.93 | BACE1 (0.89) | BACE1APPCTSDBACE2 | |
| SCHEMBL16311005 | 0.93 | BACE1 (1.00) | BACE1APPCTSDBACE2REN | |
| SCHEMBL16310982 | 0.93 | BACE1 (0.86) | BACE1APPCTSDBACE2 | |
| SCHEMBL4306222 | 0.93 | BACE1 (0.86) | BACE1APPCTSDBACE2REN | |
| SCHEMBL8157422 | 0.93 | BACE1 (0.86) | BACE1APPCTSDBACE2REN | |
| SCHEMBL13932830 | 0.93 | BACE1 (0.86) | BACE1APPCTSDBACE2REN | |
| SCHEMBL20813784 | 0.92 | BACE1 (0.85) | BACE1APPCTSDBACE2REN | |
| SCHEMBL15955559 | 0.92 | BACE1 (1.00) | BACE1APPCTSDBACE2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 30 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3653609-B1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INST RES AGING (US) | 2024-04-03 | — | — | EP | disclosed |
| US-11142505-B2 | Compositions for APP-selective BACE inhibition and uses therefor | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2021-10-12 | — | — | US | disclosed |
| US-11091444-B2 | Hydantoins that modulate BACE-mediated app processing | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2021-08-17 | — | — | US | disclosed |
| US-11091444-B2 | Hydantoins that modulate BACE-mediated app processing | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2021-08-17 | — | — | US | disclosed |
| US-10766867-B2 | Hydantoins that modulate BACE-mediated APP processing | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2020-09-08 | — | — | US | disclosed |
| US-10766867-B2 | Hydantoins that modulate BACE-mediated APP processing | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2020-09-08 | — | — | US | disclosed |
| EP-3653609-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | Buck Institute for Research on Aging (US) | 2020-05-20 | — | — | EP | disclosed |
| US-20200148648-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING | 2020-05-14 | — | — | US | disclosed |
| US-20200148648-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING | 2020-05-14 | — | — | US | disclosed |
| EP-2956443-B1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INST RES AGING (US) | 2019-09-25 | — | — | EP | disclosed |
| US-20160159746-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INST FOR RES ON AGING (US) | 2016-06-09 | — | — | US | disclosed |
| US-20160159746-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INST FOR RES ON AGING (US) | 2016-06-09 | — | — | US | disclosed |
| US-20160159746-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INST FOR RES ON AGING (US) | 2016-06-09 | — | — | US | disclosed |
| US-20160009658-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING | 2016-01-14 | — | — | US | disclosed |
| US-20160009658-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING | 2016-01-14 | — | — | US | disclosed |
| US-20160009658-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING | 2016-01-14 | — | — | US | disclosed |
| US-20140371283-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-12-18 | — | — | US | disclosed |
| US-20140371283-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-12-18 | — | — | US | disclosed |
| US-20140371283-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-12-18 | — | — | US | disclosed |
| WO-2014127042-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BUCK INSTITUTE FOR RESEARCH ON AGING (US) | 2014-08-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160159746-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BACE1, APP, BACE2 | BACE1 1/4885APP 2/4885CTSD 170/4885 |
| US-20160009658-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BACE1, APP, BACE2 | BACE1 1/4885APP 2/4885CTSD 170/4885 |
| US-11091444-B2 | Hydantoins that modulate BACE-mediated app processing | BACE1, APP, BACE2 | BACE1 1/4885APP 2/4885CTSD 170/4885 |
| US-20140371283-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BACE1, APP, BACE2 | BACE1 1/4885APP 2/4885CTSD 170/4885 |
| US-20200148648-A1 | HYDANTOINS THAT MODULATE BACE-MEDIATED APP PROCESSING | BACE1, APP, BACE2 | BACE1 1/4885APP 2/4885CTSD 170/4885 |
| US-11142505-B2 | Compositions for APP-selective BACE inhibition and uses therefor | BACE1, BACE2, APP | BACE1 1/4885APP 3/4885CTSD 88/4885 |
| US-10766867-B2 | Hydantoins that modulate BACE-mediated APP processing | BACE1, APP, BACE2 | BACE1 1/4885APP 2/4885CTSD 170/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.