Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | CASP6 | P55212 | 2/20 | 0.41 |
| ▸ | AR | P10275 | 2/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.39 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.39 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.39 |
| ▸ | AKR1C1 | Q04828 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | TTR | P02766 | 2/20 | 0.39 |
| ▸ | PPOX | P50336 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31423374 | 1.00 | TDP1 (0.45) | TDP1L3MBTL1CASP6ARATM | |
| SCHEMBL8771996 | 0.87 | AR (0.44) | TDP1L3MBTL1CASP6ARATM | |
| SCHEMBL21749965 | 0.81 | TDP1 (0.51) | TDP1L3MBTL1CASP6ATMMEN1 | |
| SCHEMBL29197041 | 0.80 | TDP1 (0.50) | TDP1L3MBTL1CASP6ATMMEN1 | |
| SCHEMBL10717546 | 0.79 | CES1 (0.38) | L3MBTL1TTRALDH1A1LMNAHTT | |
| SCHEMBL9748208 | 0.78 | TDP1 (0.46) | TDP1L3MBTL1CASP6ARATM | |
| SCHEMBL21435035 | 0.77 | TDP1 (0.47) | TDP1L3MBTL1CASP6ATMMEN1 | |
| SCHEMBL1448258 | 0.77 | TDP1 (0.47) | TDP1L3MBTL1CASP6ATMAKR1C2 | |
| SCHEMBL1448267 | 0.77 | TDP1 (0.56) | TDP1L3MBTL1CASP6ATMMEN1 | |
| SCHEMBL31146201 | 0.77 | TDP1 (0.56) | TDP1L3MBTL1CASP6ATMMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014128612-A1 | QUINAZOLIN-4-ONE DERIVATIVES | NOVARTIS AG (CH) | 2014-08-28 | — | — | WO | disclosed |