Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 7/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | KCNA5 | P22460 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.42 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.42 |
| ▸ | DRD4 | P21917 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19598387 | 1.00 | MDM2 (0.51) | MDM2MEN1KMT2AKCNA5ALDH1A1 | |
| SCHEMBL15989606 | 1.00 | MDM2 (0.51) | MDM2MEN1KMT2AKCNA5ALDH1A1 | |
| SCHEMBL15989605 | 1.00 | MDM2 (0.51) | MDM2MEN1KMT2AKCNA5ALDH1A1 | |
| SCHEMBL19598291 | 0.80 | KMT2A (0.41) | MDM2MEN1KMT2AKCNA5ALDH1A1 | |
| SCHEMBL18159810 | 0.77 | MEN1 (0.50) | MEN1KMT2AKCNA5ALDH1A1HSD17B10 | |
| SCHEMBL18150873 | 0.77 | MEN1 (0.50) | MEN1KMT2AKCNA5ALDH1A1HSD17B10 | |
| SCHEMBL18150950 | 0.77 | KMT2A (0.50) | MEN1KMT2AKCNA5ALDH1A1HSD17B10 | |
| SCHEMBL18151549 | 0.77 | MEN1 (0.50) | MEN1KMT2AKCNA5ALDH1A1HSD17B10 | |
| SCHEMBL19598272 | 0.77 | MDM2 (0.72) | MDM2TP53 | |
| SCHEMBL17402299 | 0.76 | MDM2 (0.56) | MDM2MEN1KMT2AALDH1A1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958902-B1 | CIS-MORPHOLINONE AND OTHER COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC (US) | 2017-11-15 | — | — | EP | disclosed |
| EP-2958902-A1 | CIS-MORPHOLINONE AND OTHER COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | Amgen Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130470-A1 | CIS-MORPHOLINONE AND OTHER COMPOUNDS AS MDM2 INHIBITORS FOR THE TREATMENT OF CANCER | AMGEN INC. (US) | 2014-08-28 | — | — | WO | disclosed |