Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AAK1 | Q2M2I8 | 12/20 | 0.73 |
| ▸ | ROCK2 | O75116 | 9/20 | 0.64 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15973228 | 0.86 | AAK1 (0.74) | AAK1ROCK2ROCK1 | |
| SCHEMBL15973152 | 0.85 | AAK1 (1.00) | AAK1ROCK2ROCK1 | |
| SCHEMBL15972970 | 0.83 | AAK1 (0.70) | AAK1ROCK2ROCK1 | |
| SCHEMBL18334798 | 0.82 | AAK1 (0.80) | AAK1ROCK2ROCK1 | |
| SCHEMBL15973144 | 0.82 | AAK1 (0.69) | AAK1ROCK2ROCK1 | |
| SCHEMBL15972940 | 0.81 | AAK1 (1.00) | AAK1ROCK2ROCK1 | |
| SCHEMBL15972938 | 0.81 | AAK1 (1.00) | AAK1ROCK2ROCK1 | |
| SCHEMBL15972984 | 0.81 | AAK1 (1.00) | AAK1ROCK2ROCK1 | |
| SCHEMBL15972221 | 0.80 | AAK1 (1.00) | AAK1ROCK2ROCK1 | |
| SCHEMBL15972747 | 0.79 | AAK1 (1.00) | AAK1ROCK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2958924-A1 | 5H-CHROMENO[3,4-C]PYRIDINES AS INHIBITORS OF ADAPTOR ASSOCIATED KINASE 1 (AAK1) | Bristol-Myers Squibb Company (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130258-A1 | 5H-CHROMENO[3,4-C]PYRIDINES AS INHIBITORS OF ADAPTOR ASSOCIATED KINASE 1 (AAK1) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-08-28 | — | — | WO | disclosed |