Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 20/20 | 0.65 |
| ▸ | AKT2 | P31751 | 20/20 | 0.65 |
| ▸ | AKT3 | Q9Y243 | 20/20 | 0.65 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.57 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2555660 | 1.00 | AKT1 (0.65) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2554983 | 0.96 | AKT1 (0.60) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2554651 | 0.94 | AKT1 (0.58) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2549742 | 0.92 | AKT1 (0.65) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2557858 | 0.92 | AKT1 (0.65) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2555653 | 0.92 | AKT1 (0.56) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2551724 | 0.91 | AKT1 (0.66) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2552146 | 0.89 | AKT1 (0.62) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2554841 | 0.89 | AKT1 (0.62) | AKT1AKT2AKT3PIK3CAPRKG1 | |
| SCHEMBL2556504 | 0.89 | AKT1 (0.62) | AKT1AKT2AKT3PIK3CAPRKG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2959014-A2 | METHODS AND COMPOSITIONS FOR DETECTING AND TREATING DRUG RESISTANT AKT MUTANT | Genentech, Inc. (US) | 2015-12-30 | — | — | EP | disclosed |
| WO-2014130923-A2 | METHODS AND COMPOSITIONS FOR DETECTING AND TREATING DRUG RESISTANT AKT MUTANT | GENENTECH, INC. (US) | 2014-08-28 | — | — | WO | disclosed |