Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 14/20 | 0.56 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.38 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15975453 | 0.96 | FGFR3 (0.56) | FGFR3FGFR1FGFR4KDRDRD2 | |
| SCHEMBL15976099 | 0.91 | FGFR3 (0.62) | FGFR3FGFR1FGFR4KDRDRD2 | |
| SCHEMBL14212769 | 0.87 | FGFR3 (0.54) | FGFR3FGFR1FGFR4KDRDRD2 | |
| SCHEMBL14212766 | 0.86 | FGFR3 (0.66) | FGFR3 | |
| SCHEMBL14212773 | 0.85 | FGFR3 (0.54) | FGFR3FGFR1FGFR4KDRDRD2 | |
| SCHEMBL14212762 | 0.84 | FGFR3 (0.66) | FGFR3FGFR1FGFR4 | |
| SCHEMBL1126329 | 0.81 | FGFR3 (0.59) | FGFR3FGFR1FGFR4KDRDRD2 | |
| SCHEMBL1126108 | 0.80 | FGFR3 (0.72) | FGFR3 | |
| SCHEMBL1126093 | 0.79 | FGFR3 (0.59) | FGFR3FGFR1FGFR4KDR | |
| SCHEMBL14212764 | 0.78 | FGFR3 (0.92) | FGFR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815901-B2 | Quinoline carboxamide derivatives as protein tyrosine kinase inhibitors | NOVARTIS AG (CH) | 2014-08-26 | — | — | US | disclosed |