Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 6/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | RAB9A | P51151 | 4/20 | 1.00 |
| ▸ | EPHX1 | P07099 | 6/20 | 0.74 |
| ▸ | NPC1 | O15118 | 3/20 | 0.72 |
| ▸ | MAPT | P10636 | 2/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | MEN1 | O00255 | 2/20 | 0.60 |
| ▸ | POLB | P06746 | 2/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.60 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.60 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.59 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26156272 | 0.92 | SMN1; SMN2 (0.85) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL15975494 | 0.85 | EPHX1 (0.75) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL13588408 | 0.85 | SMN1; SMN2 (0.74) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL12196171 | 0.85 | EPHX1 (1.00) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL12196179 | 0.85 | EPHX1 (1.00) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL6436349 | 0.84 | EPHX1 (1.00) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL14859647 | 0.84 | HPGD (0.72) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL4978994 | 0.84 | SMN1; SMN2 (0.72) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL2752603 | 0.83 | EPHX1 (0.97) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 | |
| SCHEMBL12196142 | 0.82 | EPHX1 (1.00) | HPGDSMN1; SMN2RAB9AEPHX1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815951-B2 | Inhibitors of epoxide hydrolases for the treatment of inflammation | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2014-08-26 | — | — | US | disclosed |