SCHEMBL15975774

SCHEMBL15975774

c1ccc(-c2ccc(-c3ccc(-c4ccc5c(c4)[Si]4(c6ccccc6-5)c5ccccc5-c5ccc(-c6ccc(-c7ccc(-c8ccccc8)cc7)cc6)cc54)cc3)cc2)cc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 2/20 0.47
MEN1 O00255 2/20 0.47
LMNA P02545 2/20 0.47
MAPT P10636 2/20 0.47
HTT P42858 2/20 0.47
KMT2A Q03164 2/20 0.47
APAF1 O14727 1/20 0.47
THRB P10828 1/20 0.47
XBP1 P17861 1/20 0.47
PTBP1 P26599 1/20 0.47
RAB9A P51151 1/20 0.47
GALK1 P51570 1/20 0.47
BLM P54132 1/20 0.47
SMAD3 P84022 1/20 0.47
ATM Q13315 1/20 0.47
SMN1; SMN2 Q16637 1/20 0.47
NPSR1 Q6W5P4 1/20 0.47
L3MBTL1 Q9Y468 1/20 0.47
NOTUM Q6P988 1/20 0.39
ALOX5 P09917 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17791403 0.89 MAPT (0.40) NPC1MEN1LMNAMAPTHTT
SCHEMBL27394474 0.86 CYP1A2 (0.45) NPC1MEN1LMNAMAPTHTT
SCHEMBL24166746 0.86 CYP1A2 (0.45) NPC1MEN1LMNAMAPTHTT
SCHEMBL20087482 0.84 NPC1 (0.48) NPC1MEN1LMNAMAPTHTT
SCHEMBL15164531 0.83 NPC1 (0.37) NPC1MEN1LMNAMAPTHTT
SCHEMBL22949336 0.82 MEN1 (0.39) NPC1MEN1LMNAMAPTHTT
SCHEMBL17791401 0.82 MAPT (0.37) NPC1MEN1LMNAMAPTHTT
SCHEMBL22572806 0.82 MEN1 (0.39) NPC1MEN1LMNAMAPTHTT
SCHEMBL22947694 0.82 MEN1 (0.39) NPC1MEN1LMNAMAPTHTT
SCHEMBL17791394 0.82 MAPT (0.37) NPC1MEN1LMNAMAPTHTT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20150287939-A1 Organic Electroluminescent Device UDC IRELAND LTD (IE) 2015-10-08 US disclosed
US-20150287939-A1 Organic Electroluminescent Device UDC IRELAND LTD (IE) 2015-10-08 US disclosed
US-8815409-B2 Organic electroluminescent device UDC IRELAND LIMITED (IE) 2014-08-26 US disclosed
US-8815409-B2 Organic electroluminescent device UDC IRELAND LIMITED (IE) 2014-08-26 US disclosed