Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 5/20 | 0.77 |
| ▸ | FYN | P06241 | 5/20 | 0.54 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.54 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | STAT6 | P42226 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL532633 | 0.91 | PIK3CA (0.74) | PIK3CAFYNKDM4EMEN1KMT2A | |
| SCHEMBL532016 | 0.87 | PIK3CA (1.00) | PIK3CAFYNKDM4EMEN1KMT2A | |
| SCHEMBL2123322 | 0.83 | PIK3CA (1.00) | PIK3CAFYNKDM4EMEN1KMT2A | |
| SCHEMBL15975812 | 0.82 | PIK3CA (0.64) | PIK3CAFYNKDM4EMEN1KMT2A | |
| SCHEMBL15975807 | 0.80 | PIK3CA (0.70) | PIK3CAKDM4EMEN1KMT2ADCTPP1 | |
| SCHEMBL532334 | 0.80 | PIK3CA (0.64) | PIK3CAFYNKDM4EALDH1A1USP2 | |
| SCHEMBL532289 | 0.80 | PIK3CA (0.67) | PIK3CAFYNKDM4EMEN1KMT2A | |
| SCHEMBL532748 | 0.79 | PIK3CA (0.63) | PIK3CAFYNKDM4EMEN1KMT2A | |
| SCHEMBL25437299 | 0.79 | MKNK1 (0.68) | PIK3CAMKNK1MKNK2KDM4EMEN1 | |
| SCHEMBL532198 | 0.78 | PIK3CA (0.61) | PIK3CAFYNKDM4EMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |