Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 11/20 | 0.88 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.43 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.40 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.39 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.39 |
| ▸ | RXRA | P19793 | 1/20 | 0.39 |
| ▸ | PRKDC | P78527 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | ATR | Q13535 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL533128 | 0.94 | PIK3CA (1.00) | PIK3CAKCNH2LOXL2NR1H2NR1H3 | |
| SCHEMBL15975826 | 0.86 | PIK3CA (0.88) | PIK3CAATR | |
| SCHEMBL15975839 | 0.84 | PIK3CA (0.66) | PIK3CA | |
| SCHEMBL15975816 | 0.84 | PIK3CA (0.63) | PIK3CA | |
| SCHEMBL15975813 | 0.83 | PIK3CA (0.71) | PIK3CA | |
| SCHEMBL15975829 | 0.83 | PIK3CA (0.61) | PIK3CA | |
| SCHEMBL15975834 | 0.82 | PIK3CA (0.67) | PIK3CA | |
| SCHEMBL2121274 | 0.81 | PIK3CA (0.78) | PIK3CAKCNH2 | |
| SCHEMBL452468 | 0.80 | PIK3CA (1.00) | PIK3CA | |
| SCHEMBL15975842 | 0.79 | PIK3CA (0.86) | PIK3CAKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815918-B2 | Imidazo [2, 1-B] [1, 3, 4] thiadiazole derivatives | CENTRO NACIONAL DE INVESTIGACIONES ONCOLOGICAS (CNIO) (ES) | 2014-08-26 | — | — | US | disclosed |