Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 20/20 | 0.86 |
| ▸ | JAK1 | P23458 | 1/20 | 0.57 |
| ▸ | TYK2 | P29597 | 1/20 | 0.57 |
| ▸ | JAK3 | P52333 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL138876 | 0.92 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL138391 | 0.92 | JAK2 (0.86) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL140480 | 0.91 | JAK2 (0.84) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL15976448 | 0.89 | JAK2 (0.73) | JAK2 | |
| SCHEMBL142342 | 0.88 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL141342 | 0.87 | JAK2 (0.82) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL139518 | 0.87 | JAK2 (0.82) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL143055 | 0.86 | JAK2 (0.78) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL140378 | 0.86 | JAK2 (1.00) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL141319 | 0.86 | JAK2 (0.80) | JAK2JAK1TYK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8815840-B2 | Carbazole and carboline kinase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 2014-08-26 | — | — | US | disclosed |