Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 14/20 | 0.74 |
| ▸ | HSP90AB1 | P08238 | 10/20 | 0.74 |
| ▸ | HSP90B1 | P14625 | 6/20 | 0.74 |
| ▸ | TRAP1 | Q12931 | 6/20 | 0.74 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.74 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.50 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3465421 | 0.87 | HSP90AA1 (0.66) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| SCHEMBL18460297 | 0.87 | ERBB2 (0.57) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| SCHEMBL11980434 | 0.86 | HSP90AA1 (0.82) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| SCHEMBL5131899 | 0.85 | HSP90AA1 (0.59) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| SCHEMBL1864188 | 0.85 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| Pu-H71 SCHEMBL1857579 | 0.85 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| Pu-H71 SCHEMBL15980469 | 0.85 | HSP90AA1 (0.81) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| SCHEMBL21792262 | 0.85 | HSP90AA1 (0.84) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| Pu-H71 SCHEMBL15980498 | 0.85 | HSP90AA1 (0.81) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 | |
| Pu-H71 SCHEMBL29414148 | 0.85 | HSP90AA1 (1.00) | HSP90AA1HSP90AB1HSP90B1TRAP1ERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3709022-A1 | USES OF LABELED HSP90 INHIBITORS | Sloan-Kettering Institute for Cancer Research (US) | 2020-09-16 | — | — | EP | disclosed |
| EP-3208615-B1 | USES OF LABELED HSP90 INHIBITORS | SLOAN KETTERING INST CANCER RES (US) | 2019-10-09 | — | — | EP | disclosed |
| EP-3208615-A2 | USES OF LABELED HSP90 INHIBITORS | Sloan Kettering Institute For Cancer Research (US) | 2017-08-23 | — | — | EP | disclosed |
| EP-2729806-B1 | USES OF LABELED HSP90 INHIBITORS | SLOAN-KETTERING INST FOR CANCER RES (US) | 2017-02-22 | — | — | EP | disclosed |
| US-20170029426-A1 | METHODS AND REAGENTS FOR RADIOLABELING | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2017-02-02 | — | — | US | disclosed |
| US-9555137-B2 | Uses of labeled HSP90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2017-01-31 | — | — | US | disclosed |
| US-9555137-B2 | Uses of labeled HSP90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2017-01-31 | — | — | US | disclosed |
| WO-2015138039-A1 | METHODS AND REAGENTS FOR RADIOLABELING | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2015-09-17 | — | — | WO | disclosed |
| US-20140294725-A1 | USES OF LABELED HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140294725-A1 | USES OF LABELED HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140242602-A1 | USES OF LABELED HSP90 INHIBITORS | CORNELL UNIVERSITY (US) | 2014-08-28 | — | — | US | disclosed |
| US-20140242602-A1 | USES OF LABELED HSP90 INHIBITORS | CORNELL UNIVERSITY (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170029426-A1 | METHODS AND REAGENTS FOR RADIOLABELING | HSP90AB1, HSP90B1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885HSP90B1 2/4885 |
| US-20140294725-A1 | USES OF LABELED HSP90 INHIBITORS | HSP90AB1, HSP90B1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885HSP90B1 2/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.