Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 15/20 | 0.67 |
| ▸ | HSP90AB1 | P08238 | 12/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.67 |
| ▸ | HSP90B1 | P14625 | 5/20 | 0.67 |
| ▸ | TRAP1 | Q12931 | 3/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17449240 | 0.97 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL15980494 | 0.93 | HSP90AA1 (0.74) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL11909860 | 0.90 | HSP90AA1 (0.79) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL15980478 | 0.90 | HSP90AA1 (0.67) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL15980500 | 0.89 | HSP90AB1 (0.56) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL1669649 | 0.89 | HSP90AA1 (0.79) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL17449244 | 0.89 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL17449247 | 0.89 | HSP90AA1 (0.64) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| SCHEMBL17449248 | 0.89 | HSP90AA1 (0.79) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 | |
| Pu-H71 SCHEMBL15980469 | 0.88 | HSP90AA1 (0.81) | HSP90AA1HSP90AB1ERBB2HSP90B1TRAP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170304470-A1 | HSP90-TARGETED INFLAMMATION AND INFECTION IMAGING AND THERAPY | MEMORIAL SLOAN KETTERING CANCER CENTER (US) | 2017-10-26 | — | — | US | disclosed |
| US-9555137-B2 | Uses of labeled HSP90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2017-01-31 | — | — | US | disclosed |
| US-20160015837-A1 | HSP90-TARGETED CARDIAC IMAGING AND THERAPY | MEMORIAL SLOAN-KETTERING CANCER CENTER | 2016-01-21 | — | — | US | disclosed |
| US-20140294725-A1 | USES OF LABELED HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2014-10-02 | — | — | US | disclosed |
| US-20140242602-A1 | USES OF LABELED HSP90 INHIBITORS | CORNELL UNIVERSITY (US) | 2014-08-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170304470-A1 | HSP90-TARGETED INFLAMMATION AND INFECTION IMAGING AND THERAPY | HSP90AB1, HSP90AA1, HSP90B1 | HSP90AA1 2/4885HSP90AB1 1/4885ERBB2 79/4885 |
| US-20160015837-A1 | HSP90-TARGETED CARDIAC IMAGING AND THERAPY | HSP90AB1, HSP90AA1, HSP90B1 | HSP90AA1 2/4885HSP90AB1 1/4885ERBB2 52/4885 |
| US-20140294725-A1 | USES OF LABELED HSP90 INHIBITORS | HSP90AB1, HSP90B1, HSP90AA1 | HSP90AA1 3/4885HSP90AB1 1/4885ERBB2 690/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.