Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 20/20 | 0.50 |
| ▸ | LCK | P06239 | 2/20 | 0.46 |
| ▸ | JAK2 | O60674 | 2/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | STAT3 | P40763 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15988152 | 0.86 | JAK3 (0.52) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL15988066 | 0.85 | AKT2 (0.58) | JAK3 | |
| SCHEMBL15988105 | 0.85 | AKT2 (0.53) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL15988548 | 0.85 | JAK3 (0.52) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL15988073 | 0.85 | JAK3 (0.52) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL15987992 | 0.84 | KIT (0.54) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL15988588 | 0.84 | JAK3 (0.54) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL15988078 | 0.84 | AKT2 (0.55) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL15987944 | 0.83 | JAK3 (0.49) | JAK3LCKJAK2JAK1TYK2 | |
| SCHEMBL15988076 | 0.83 | AKT2 (0.52) | JAK3LCKJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2590981-B1 | NOVEL HOMOPIPERAZINE DERIVATIVES AS PROTEIN TYROSINE KINASE INHIBITORS AND PHARMACEUTICAL USE THEREOF | LEO PHARMA AS (DK) | 2014-09-03 | — | — | EP | disclosed |