Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 12/20 | 0.65 |
| ▸ | CYP3A4 | P08684 | 7/20 | 0.65 |
| ▸ | KIT | P10721 | 2/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.53 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.53 |
| ▸ | MTOR | P42345 | 7/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ATR | Q13535 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5261939 | 0.81 | MAPK14 (0.65) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2949832 | 0.79 | MAPK14 (1.00) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2944350 | 0.78 | MAPK14 (1.00) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2945978 | 0.78 | MAPK14 (1.00) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2953268 | 0.77 | MAPK14 (1.00) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2955984 | 0.77 | MAPK14 (1.00) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2955992 | 0.77 | MAPK14 (1.00) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2951782 | 0.76 | MAPK14 (0.84) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2953518 | 0.75 | MAPK14 (1.00) | MAPK14CYP3A4KITPDGFRBKCNH2 | |
| SCHEMBL2946012 | 0.75 | MAPK14 (1.00) | MAPK14CYP3A4KITPDGFRBKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856058-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2014-09-03 | — | — | EP | claimed |