Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 19/20 | 0.67 |
| ▸ | KIT | P10721 | 10/20 | 0.67 |
| ▸ | KDR | P35968 | 9/20 | 0.67 |
| ▸ | LCK | P06239 | 6/20 | 0.67 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.65 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.65 |
| ▸ | LYN | P07948 | 1/20 | 0.55 |
| ▸ | CSF1R | P07333 | 1/20 | 0.49 |
| ▸ | SGK1 | O00141 | 1/20 | 0.47 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.46 |
| ▸ | RAF1 | P04049 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2948851 | 0.83 | MAPK14 (0.69) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2948130 | 0.82 | MAPK14 (0.61) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2954438 | 0.82 | MAPK14 (0.87) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2955298 | 0.81 | MAPK14 (0.79) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2947386 | 0.81 | MAPK14 (1.00) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2954441 | 0.80 | MAPK14 (0.81) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2944572 | 0.80 | MAPK14 (0.84) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2951825 | 0.80 | MAPK14 (0.80) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2953214 | 0.79 | MAPK14 (1.00) | MAPK14KITKDRLCKMAPK9 | |
| SCHEMBL2952646 | 0.79 | MAPK14 (0.70) | MAPK14KITKDRLCKMAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1856058-B1 | PHTHALAZINE, AZA- AND DIAZA-PHTHALAZINE COMPOUNDS AND METHODS OF USE | AMGEN INC (US) | 2014-09-03 | — | — | EP | claimed |