Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 4/20 | 0.52 |
| ▸ | PDE4A | P27815 | 3/20 | 0.52 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.52 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.52 |
| ▸ | BRD4 | O60885 | 6/20 | 0.34 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | CASP3 | P42574 | 1/20 | 0.31 |
| ▸ | CDK9 | P50750 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.31 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1411693 | 1.00 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL1411224 | 0.93 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL1411189 | 0.92 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL1411230 | 0.90 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL1411369 | 0.89 | PDE4D (0.48) | PDE4DPDE4APDE4BPDE4CKDM4E | |
| SCHEMBL16004721 | 0.87 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL1411281 | 0.87 | PDE4D (0.47) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL1411594 | 0.87 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL29565987 | 0.87 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CBRD4 | |
| SCHEMBL15282316 | 0.87 | PDE4D (0.52) | PDE4DPDE4APDE4BPDE4CBRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829189-B2 | Salts of 6-heterocycle substituted hexahydrophenanthridine derivatives | TAKEDA GMBH (DE) | 2014-09-09 | — | — | US | disclosed |