Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCD | O00767 | 15/20 | 0.80 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.44 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | DCTPP1 | Q9H773 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1599829 | 0.93 | SCD (0.80) | SCDHCRTR1HCRTR2NAMPT | |
| SCHEMBL1601541 | 0.89 | SCD (1.00) | SCDDCTPP1 | |
| SCHEMBL2464954 | 0.86 | SCD (0.59) | SCDHCRTR1HCRTR2 | |
| SCHEMBL1380395 | 0.85 | SCD (0.79) | SCDDCTPP1 | |
| SCHEMBL2719681 | 0.82 | SCD (0.55) | SCDHCRTR1HCRTR2 | |
| SCHEMBL2463361 | 0.79 | SCD (0.59) | SCDHCRTR1HCRTR2 | |
| SCHEMBL1599640 | 0.79 | SCD (0.88) | SCDDCTPP1 | |
| SCHEMBL1378951 | 0.79 | SCD (0.79) | SCDDCTPP1 | |
| SCHEMBL1599652 | 0.77 | SCD (0.80) | SCDDCTPP1 | |
| SCHEMBL1385471 | 0.77 | SCD (0.78) | SCDDCTPP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1846035-B1 | COMBINATION THERAPY | XENON PHARMACEUTICALS INC (CA) | 2011-09-21 | — | — | EP | claimed |
| EP-1846035-B1 | COMBINATION THERAPY | XENON PHARMACEUTICALS INC (CA) | 2011-09-21 | — | — | EP | disclosed |
| US-7919484-B2 | Combination therapy | XENON PHARMACEUTICALS INC. (CA) | 2011-04-05 | — | — | US | disclosed |