Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | GLA | P06280 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | CYP1A1 | P04798 | 2/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.37 |
| ▸ | CYP1B1 | Q16678 | 2/20 | 0.37 |
| ▸ | XDH | P47989 | 1/20 | 0.37 |
| ▸ | ANO1 | Q5XXA6 | 1/20 | 0.37 |
| ▸ | PTGER1 | P34995 | 4/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2995277 | 0.92 | KDM4E (0.46) | HPGDKDM4EGLAMAPTTSHR | |
| SCHEMBL3000516 | 0.89 | KDM4E (0.39) | HPGDKDM4EGLAMAPTTSHR | |
| SCHEMBL2995853 | 0.85 | KDM4E (0.40) | HPGDKDM4EGLAMAPTTSHR | |
| SCHEMBL2991598 | 0.80 | KDM4E (0.44) | HPGDKDM4EGLAMAPTTSHR | |
| SCHEMBL2992434 | 0.79 | HPGD (0.38) | HPGDKDM4EGLAMAPTTSHR | |
| SCHEMBL14403823 | 0.77 | HPGD (0.37) | HPGDKDM4EGLAMAPTTSHR | |
| SCHEMBL2989466 | 0.77 | KDM4E (0.46) | KDM4EMAPTTSHRHSD17B10TDP1 | |
| SCHEMBL13890320 | 0.74 | HIF1A (0.36) | HPGDKDM4EGLAMAPTTSHR | |
| SCHEMBL12091770 | 0.72 | PTGER4 (0.45) | HPGDKDM4EMAPTTSHRHTT | |
| SCHEMBL13890316 | 0.70 | TSHR (0.36) | HPGDKDM4EGLAMAPTTSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809601-B1 | COMPOUNDS FOR ALZHEIMER'S DISEASE | MANFREDI JOHN (US) | 2014-09-10 | — | — | EP | disclosed |