Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MERTK | Q12866 | 3/20 | 0.47 |
| ▸ | PTGER4 | P35408 | 3/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | HPGDS | O60760 | 1/20 | 0.41 |
| ▸ | FLT3 | P36888 | 1/20 | 0.41 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.41 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.41 |
| ▸ | PTGER2 | P43116 | 1/20 | 0.41 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3408185 | 0.93 | EGLN1 (0.52) | EGLN1MERTKHPGDSFLT3TYRO3 | |
| SCHEMBL4527994 | 0.91 | EGLN1 (0.64) | EGLN1MERTKNR1H4EPHX2 | |
| SCHEMBL3404889 | 0.90 | EGLN1 (0.48) | EGLN1MERTKKMT2AFLT3TYRO3 | |
| SCHEMBL3407244 | 0.89 | EGLN1 (0.51) | EGLN1LMNAMERTKKMT2AFLT3 | |
| SCHEMBL3430237 | 0.89 | EGLN1 (0.51) | EGLN1MERTKKMT2AFLT3TYRO3 | |
| SCHEMBL3409246 | 0.89 | EGLN1 (0.64) | EGLN1LMNAMERTK | |
| SCHEMBL16005726 | 0.88 | EGLN1 (0.46) | EGLN1LMNAMERTKPTGER4NR1H4 | |
| SCHEMBL4538093 | 0.88 | EGLN1 (0.52) | EGLN1LMNAMERTKPTGER4 | |
| SCHEMBL3404652 | 0.88 | EGLN1 (0.56) | EGLN1MERTKKMT2A | |
| SCHEMBL4521549 | 0.87 | EGLN1 (0.53) | EGLN1MERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2257539-B1 | SUBSTITUTED 4-HYDROXYPYRIMIDINE-5-CARBOXAMIDES | MERCK SHARP & DOHME (US) | 2014-09-10 | — | — | EP | claimed |