Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 13/20 | 0.79 |
| ▸ | DYRK2 | Q92630 | 13/20 | 0.79 |
| ▸ | DYRK1B | Q9Y463 | 13/20 | 0.79 |
| ▸ | DYRK3 | O43781 | 12/20 | 0.79 |
| ▸ | CDK5 | Q00535 | 10/20 | 0.79 |
| ▸ | CDK5R1 | Q15078 | 10/20 | 0.79 |
| ▸ | CCNT1 | O60563 | 9/20 | 0.79 |
| ▸ | CDK9 | P50750 | 9/20 | 0.79 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.79 |
| ▸ | CDK2 | P24941 | 8/20 | 0.79 |
| ▸ | FYN | P06241 | 6/20 | 0.64 |
| ▸ | ABL1 | P00519 | 1/20 | 0.52 |
| ▸ | PGK1 | P00558 | 1/20 | 0.52 |
| ▸ | CDK1 | P06493 | 1/20 | 0.52 |
| ▸ | PIM1 | P11309 | 1/20 | 0.52 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.52 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.52 |
| ▸ | GSK3A | P49840 | 1/20 | 0.52 |
| ▸ | GSK3B | P49841 | 1/20 | 0.52 |
| ▸ | JAK3 | P52333 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16017040 | 1.00 | DYRK1A (0.79) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL2946492 | 0.86 | CCNT1 (0.76) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL2946487 | 0.86 | CCNT1 (0.76) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL16009360 | 0.84 | FYN (0.71) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL13234623 | 0.83 | FYN (0.79) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL16010655 | 0.81 | FYN (0.81) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL16010383 | 0.80 | FYN (0.88) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL16009855 | 0.80 | CCNT1 (0.69) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL2941614 | 0.79 | FYN (0.75) | DYRK1ADYRK2DYRK1BDYRK3CDK5 | |
| SCHEMBL2949403 | 0.78 | FYN (1.00) | DYRK1ADYRK2DYRK1BDYRK3CDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160228437-A1 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS | Califia Bio, Inc. | 2016-08-11 | — | — | US | disclosed |
| US-9370515-B2 | Mixed lineage kinase inhibitors and method of treatments | Califia Bio, Inc. (US) | 2016-06-21 | — | — | US | disclosed |
| US-20140256733-A1 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS | Califia Bio, Inc. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160228437-A1 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS | MAP3K2, MAP3K1, MAP3K20 | DYRK1A 442/4885DYRK2 402/4885DYRK1B 439/4885 |
| US-20140256733-A1 | MIXED LINEAGE KINASE INHIBITORS AND METHOD OF TREATMENTS | MAP3K2, MAP3K1, MAP3K20 | DYRK1A 442/4885DYRK2 402/4885DYRK1B 439/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.