Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Toreforant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 known ✓ | Q9H3N8 | 10/20 | 0.86 |
| ▸ | SSTR2 | P30874 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | FLT3 | P36888 | 5/20 | 0.34 |
| ▸ | TYRO3 | Q06418 | 5/20 | 0.34 |
| ▸ | GAS6 | Q14393 | 5/20 | 0.34 |
| ▸ | MERTK | Q12866 | 4/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 1/20 | 0.34 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.34 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.34 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.34 |
| ▸ | DHODH | Q02127 | 1/20 | 0.33 |
| ▸ | IGF1R | P08069 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | AXL | P30530 | 1/20 | 0.32 |
| ▸ | CARM1 | Q86X55 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Toreforant SCHEMBL16010699 | 1.00 | HRH4 (0.86) | HRH4SSTR2KCNH2FLT3TYRO3 | |
| Toreforant SCHEMBL1535698 | 0.93 | HRH4 (1.00) | HRH4SSTR2KCNH2FLT3TYRO3 | |
| Toreforant SCHEMBL29378793 | 0.93 | HRH4 (1.00) | HRH4SSTR2KCNH2FLT3TYRO3 | |
| Toreforant SCHEMBL16010696 | 0.92 | HRH4 (0.85) | HRH4SSTR2KCNH2FLT3TYRO3 | |
| Toreforant SCHEMBL16010698 | 0.91 | HRH4 (0.90) | HRH4SSTR2KCNH2FLT3TYRO3 | |
| Toreforant SCHEMBL16010688 | 0.91 | HRH4 (0.84) | HRH4SSTR2KCNH2FLT3TYRO3 | |
| Toreforant SCHEMBL16010707 | 0.91 | HRH4 (0.84) | HRH4SSTR2KCNH2FLT3TYRO3 | |
| SCHEMBL2914884 | 0.85 | HRH4 (0.84) | HRH4FLT3TYRO3GAS6FGFR1 | |
| SCHEMBL2913640 | 0.85 | HRH4 (1.00) | HRH4SSTR2KCNH2FLT3TYRO3 | |
| SCHEMBL16022675 | 0.85 | HRH4 (0.84) | HRH4SSTR2KCNH2CARM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3660011-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica NV (BE) | 2020-06-03 | — | — | EP | disclosed |
| US-9663497-B2 | Benzoimidazol-2-yl pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2017-05-30 | — | — | US | disclosed |
| US-20160340337-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | NOVASSAY S.A. (CH) | 2016-11-24 | — | — | US | disclosed |
| US-9434715-B2 | Benzoimidazol-2-yl pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2016-09-06 | — | — | US | disclosed |
| US-20160159775-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2016-06-09 | — | — | US | disclosed |
| US-9278952-B2 | Benzoimidazol-2-yl pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2016-03-08 | — | — | US | disclosed |
| EP-2964229-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2016-01-13 | — | — | EP | disclosed |
| US-20140364607-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2014-12-11 | — | — | US | disclosed |
| US-8859575-B2 | Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2014-10-14 | — | — | US | disclosed |
| WO-2014138368-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2014-09-12 | — | — | WO | disclosed |
| US-20140256942-A1 | Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor | JANSSEN PHARMACEUTICA NV (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160340337-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | HRH4 1/4885SSTR2 1302/4885KCNH2 504/4885 |
| US-20140364607-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | HRH4 1/4885SSTR2 1302/4885KCNH2 504/4885 |
| US-20140256942-A1 | Benzoimidazol-2-yl pyrimidine modulators of the histamine h4 receptor | HRH4, HRH3, HRH2 | HRH4 1/4885SSTR2 1302/4885KCNH2 504/4885 |
| US-20160159775-A1 | BENZOIMIDAZOL-2-YL PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | HRH4 1/4885SSTR2 1302/4885KCNH2 504/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.