Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNKS2 | Q9H2K2 | 10/20 | 1.00 |
| ▸ | TNKS | O95271 | 5/20 | 1.00 |
| ▸ | TP53 | P04637 | 7/20 | 0.93 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.93 |
| ▸ | MAPT | P10636 | 7/20 | 0.91 |
| ▸ | THRB | P10828 | 3/20 | 0.91 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.86 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.86 |
| ▸ | AXIN2 | Q9Y2T1 | 2/20 | 0.86 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.86 |
| ▸ | SULT2A1 | Q06520 | 1/20 | 0.86 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.86 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.74 |
| ▸ | LMNA | P02545 | 2/20 | 0.72 |
| ▸ | HTT | P42858 | 1/20 | 0.72 |
| ▸ | MEN1 | O00255 | 1/20 | 0.68 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.68 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11919898 | 0.93 | TNKS2 (1.00) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL11919903 | 0.91 | TP53 (1.00) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL11919910 | 0.88 | SMN1; SMN2 (0.84) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL16447499 | 0.84 | TNKS2 (1.00) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL11919908 | 0.84 | NPSR1 (0.90) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL11919900 | 0.84 | TNKS2 (0.83) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL6403463 | 0.82 | CYP3A4 (0.73) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL11919921 | 0.82 | TNKS2 (0.76) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL11919906 | 0.82 | TP53 (0.82) | TNKS2TNKSTP53SMN1; SMN2MAPT | |
| SCHEMBL11919923 | 0.81 | MAPT (0.76) | TNKS2TNKSTP53SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140255426-A1 | WNT PATHWAY INHIBITORS FOR TREATING VIRAL INFECTIONS | EMORY UNIVERSITY (US) | 2014-09-11 | — | — | US | disclosed |