Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MME | P08473 | 20/20 | 0.78 |
| ▸ | ACE | P12821 | 12/20 | 0.78 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16008688 | 1.00 | MME (0.78) | MMEACEMMEL1 | |
| SCHEMBL16008239 | 0.88 | MME (0.80) | MMEACEMMEL1 | |
| SCHEMBL14890447 | 0.88 | MME (1.00) | MMEACEMMEL1 | |
| SCHEMBL18597868 | 0.88 | MME (1.00) | MMEACEMMEL1 | |
| SCHEMBL16008124 | 0.87 | MME (0.77) | MMEACEMMEL1 | |
| SCHEMBL16011808 | 0.87 | MME (0.77) | MMEACEMMEL1 | |
| SCHEMBL16008640 | 0.84 | MME (0.80) | MMEACEMMEL1 | |
| SCHEMBL16008005 | 0.84 | MME (0.73) | MMEACEMMEL1 | |
| SCHEMBL16008040 | 0.84 | MME (0.73) | MMEACE | |
| SCHEMBL16008712 | 0.84 | MME (0.76) | MMEACEMMEL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964616-A1 | NEPRILYSIN INHIBITORS | Theravance Biopharma R&D IP, LLC (US) | 2016-01-13 | — | — | EP | disclosed |
| WO-2014138053-A1 | NEPRILYSIN INHIBITORS | THERAVANCE BIOPHARMA R&D IP, LLC (US) | 2014-09-12 | — | — | WO | disclosed |