Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 2/20 | 0.51 |
| ▸ | GSK3B | P49841 | 2/20 | 0.51 |
| ▸ | MAPK6 | Q16659 | 10/20 | 0.50 |
| ▸ | EIF2AK4 | Q9P2K8 | 8/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830501 | 1.00 | GSK3A (0.51) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL17448119 | 1.00 | GSK3A (0.51) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16012659 | 0.92 | GSK3A (0.59) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL17435275 | 0.92 | GSK3A (0.59) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16013042 | 0.92 | GSK3A (0.59) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL18813081 | 0.89 | GSK3A (0.55) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16012401 | 0.88 | MAPK6 (0.55) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16013764 | 0.87 | MAPK6 (0.63) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16012012 | 0.87 | MAPK6 (0.63) | GSK3AGSK3BMAPK6EIF2AK4 | |
| SCHEMBL16011889 | 0.87 | MAPK6 (0.63) | GSK3AGSK3BMAPK6EIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2964649-A1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | Merck Patent GmbH (DE) | 2016-01-13 | — | — | EP | claimed |
| WO-2014135244-A1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2014-09-12 | — | — | WO | claimed |