Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 14/20 | 0.50 |
| ▸ | FLT1 | P17948 | 8/20 | 0.50 |
| ▸ | FLT3 | P36888 | 8/20 | 0.50 |
| ▸ | KIT | P10721 | 8/20 | 0.50 |
| ▸ | CSF1R | P07333 | 6/20 | 0.50 |
| ▸ | FLT4 | P35916 | 6/20 | 0.50 |
| ▸ | TEK | Q02763 | 5/20 | 0.50 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.50 |
| ▸ | LCK | P06239 | 5/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 4/20 | 0.50 |
| ▸ | AURKA | O14965 | 4/20 | 0.50 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.50 |
| ▸ | AURKB | Q96GD4 | 3/20 | 0.50 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.50 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.50 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.50 |
| ▸ | MAPK9 | P45984 | 4/20 | 0.48 |
| ▸ | RPS6KA3 | P51812 | 4/20 | 0.48 |
| ▸ | RET | P07949 | 3/20 | 0.48 |
| ▸ | FRK | P42685 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL276439 | 0.92 | KDR (0.51) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL16015577 | 0.91 | KDR (0.51) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL327885 | 0.89 | KDR (0.49) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL327935 | 0.85 | FLT3 (0.65) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL10273031 | 0.85 | KDR (0.54) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL328044 | 0.84 | FLT3 (0.57) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL16015587 | 0.83 | KDR (0.52) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL279558 | 0.83 | KDR (0.53) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL275484 | 0.83 | KDR (0.53) | KDRFLT1FLT3KITCSF1R | |
| SCHEMBL275020 | 0.82 | FLT3 (0.62) | KDRFLT1FLT3KITCSF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8829185-B2 | Substituted 4-amino-pyrrolotriazine derivatives useful for treating hyper-proliferative disorders and diseases associated with angiogenesis | BAYER HEALTHCARE LLC (US) | 2014-09-09 | — | — | US | disclosed |