Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.48 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.45 |
| ▸ | TSHR | P16473 | 3/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.44 |
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13557795 | 0.81 | CYP19A1 (0.53) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL24249845 | 0.81 | CYP19A1 (0.53) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL13059722 | 0.80 | CYP19A1 (0.41) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL7133227 | 0.80 | CYP19A1 (0.41) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL5556173 | 0.80 | CYP19A1 (0.41) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL1286336 | 0.78 | EPHX1 (0.53) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL16622496 | 0.78 | EPHX1 (0.53) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL18596846 | 0.78 | CYP19A1 (0.60) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL10171231 | 0.78 | CYP19A1 (0.60) | CYP19A1EPHX1MAPTNPSR1TSHR | |
| SCHEMBL12952148 | 0.78 | CYP19A1 (0.60) | CYP19A1EPHX1MAPTNPSR1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE45128-E1 | Cephalotaxane derivatives and their processes of preparation and purification | IVAX International GmbH (CH) | 2014-09-09 | — | — | US | disclosed |