Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SERPINE1 | P05121 | 1/20 | 0.45 |
| ▸ | GRM5 | P41594 | 3/20 | 0.33 |
| ▸ | PARP1 | P09874 | 1/20 | 0.33 |
| ▸ | SRD5A1 | P18405 | 1/20 | 0.33 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | SLC11A2 | P49281 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | AKT1 | P31749 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2996128 | 0.89 | SERPINE1 (0.52) | SERPINE1SRD5A1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL12091824 | 0.80 | SERPINE1 (0.51) | SERPINE1PARP1SRD5A1SRD5A2MAPT | |
| SCHEMBL12091799 | 0.78 | SERPINE1 (0.62) | SERPINE1SRD5A1SRD5A2SMN1; SMN2MEN1 | |
| SCHEMBL2994258 | 0.76 | KDM4E (0.42) | SERPINE1GRM5HTR1AHTR7 | |
| SCHEMBL2993810 | 0.74 | SERPINE1 (0.60) | SERPINE1SRD5A1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL2996651 | 0.74 | SERPINE1 (0.69) | SERPINE1SRD5A1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL2981885 | 0.74 | SERPINE1 (0.52) | SERPINE1GRM5SRD5A1SRD5A2MAPT | |
| SCHEMBL2994026 | 0.73 | SERPINE1 (0.64) | SERPINE1PARP1SRD5A1SRD5A2MAPT | |
| SCHEMBL2987677 | 0.72 | SERPINE1 (0.63) | SERPINE1SRD5A1SRD5A2MAPTSMN1; SMN2 | |
| SCHEMBL2991502 | 0.72 | SERPINE1 (0.57) | SERPINE1SRD5A1SRD5A2MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1809601-B1 | COMPOUNDS FOR ALZHEIMER'S DISEASE | MANFREDI JOHN (US) | 2014-09-10 | — | — | EP | disclosed |