Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | MITF | O75030 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | F2 | P00734 | 1/20 | 0.48 |
| ▸ | PLG | P00747 | 1/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28924563 | 0.79 | PBRM1 (0.52) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL125621 | 0.78 | PBRM1 (0.87) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL9282073 | 0.78 | PBRM1 (0.87) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL5091376 | 0.78 | PBRM1 (0.65) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL29363032 | 0.78 | PBRM1 (0.87) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL3981731 | 0.77 | PBRM1 (0.50) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL8776892 | 0.77 | PBRM1 (0.50) | PBRM1NPC1MITFLMNAPOLB | |
| SCHEMBL8003710 | 0.77 | PBRM1 (0.59) | PBRM1NPC1MITFLMNAPOLB | |
| 3-Aminobenzoic Acid SCHEMBL27648 | 0.76 | PBRM1 (0.69) | PBRM1NPC1MITFLMNAPOLB | |
| 3-Aminobenzamide SCHEMBL16070 | 0.76 | PBRM1 (0.63) | PBRM1NPC1MITFLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2563123-B1 | NOVEL BETA 3 ADRENERGIC RECEPTOR AGONISTS | MERCK SHARP & DOHME (US) | 2018-04-25 | — | — | EP | disclosed |
| WO-2018053353-A1 | KETONE INHIBITORS OF LYSINE GINGIPAIN | Cortexyme, Inc. (US) | 2018-03-22 | — | — | WO | disclosed |
| EP-1809601-B1 | COMPOUNDS FOR ALZHEIMER'S DISEASE | MANFREDI JOHN (US) | 2014-09-10 | — | — | EP | disclosed |