Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | NPY5R | Q15761 | 4/20 | 0.33 |
| ▸ | PGR | P06401 | 3/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | LTA4H | P09960 | 1/20 | 0.32 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8422637 | 0.79 | KMT2A (0.41) | KMT2AJAK2JAK1TSHRCYP2D6 | |
| SCHEMBL8427910 | 0.78 | KMT2A (0.42) | KMT2AJAK2JAK1TSHRCYP2D6 | |
| SCHEMBL20458810 | 0.78 | TP53 (0.41) | JAK2JAK1NPSR1TP53NPY5R | |
| SCHEMBL774018 | 0.78 | KMT2A (0.43) | KMT2AJAK2JAK1TSHRCYP2D6 | |
| SCHEMBL8246290 | 0.75 | KMT2A (0.41) | KMT2AJAK2JAK1TSHRCYP2D6 | |
| SCHEMBL8282088 | 0.75 | JAK2 (0.44) | KMT2AJAK2JAK1TSHRCYP2D6 | |
| SCHEMBL8280875 | 0.75 | JAK2 (0.44) | KMT2AJAK2JAK1TSHRCYP2D6 | |
| SCHEMBL8280862 | 0.75 | JAK2 (0.44) | KMT2AJAK2JAK1TSHRCYP2D6 | |
| SCHEMBL8239163 | 0.73 | KMT2A (0.39) | KMT2AJAK2JAK1TSHRCYP2D6 | |
| SCHEMBL8248983 | 0.73 | KMT2A (0.42) | KMT2AJAK2JAK1TSHRCYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1871772-B1 | QUINOLINONE COMPOUNDS AS 5-HT4 RECEPTOR AGONISTS | THERAVANCE INC (US) | 2014-09-10 | — | — | EP | disclosed |