Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 10/20 | 0.53 |
| ▸ | TLR7 | Q9NYK1 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.45 |
| ▸ | JAK1 | P23458 | 1/20 | 0.45 |
| ▸ | TYK2 | P29597 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.45 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.45 |
| ▸ | SCN10A | Q9Y5Y9 | 1/20 | 0.45 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14887512 | 0.93 | TLR8 (0.49) | TLR8TLR7KDM4ENPC1ALDH1A1 | |
| SCHEMBL14887503 | 0.92 | S1PR3 (0.48) | TLR8TLR7S1PR3SCN8ASCN10A | |
| SCHEMBL14887505 | 0.91 | TLR8 (0.48) | TLR8TLR7NPC1S1PR3CDK8 | |
| SCHEMBL14887511 | 0.90 | S1PR3 (0.47) | TLR8TLR7KDM4ENPC1ALDH1A1 | |
| SCHEMBL16017353 | 0.89 | S1PR3 (0.44) | TLR8TLR7KDM4ENPC1ALDH1A1 | |
| SCHEMBL14887609 | 0.89 | TLR8 (0.52) | TLR8TLR7KDM4ENPC1ALDH1A1 | |
| SCHEMBL14887500 | 0.88 | TLR8 (0.61) | TLR8NPC1LMNAHTTSMN1; SMN2 | |
| SCHEMBL16017365 | 0.87 | S1PR3 (0.44) | TLR8TLR7KDM4ENPC1ALDH1A1 | |
| SCHEMBL14887507 | 0.85 | S1PR3 (0.45) | TLR8TLR7S1PR3LMNAHTT | |
| SCHEMBL16017377 | 0.85 | TLR8 (0.49) | TLR8TLR7KDM4ENPC1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256771-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | TLR8 4453/4885TLR7 4757/4885KDM4E 4057/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.