Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 4/20 | 0.49 |
| ▸ | ORAI1 | Q96D31 | 4/20 | 0.49 |
| ▸ | ORAI2 | Q96SN7 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.38 |
| ▸ | RAB9A | P51151 | 3/20 | 0.38 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | BRAF | P15056 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.35 |
| ▸ | AKT1 | P31749 | 2/20 | 0.35 |
| ▸ | KDR | P35968 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | IL2 | P60568 | 2/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16018185 | 0.91 | STIM1 (0.51) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16018193 | 0.90 | STIM1 (0.50) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16017240 | 0.88 | STIM1 (0.41) | STIM1ORAI1ORAI2KDRALDH1A1 | |
| SCHEMBL16018244 | 0.87 | STIM1 (0.62) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16020571 | 0.84 | STIM1 (0.48) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16018214 | 0.82 | STIM1 (0.55) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL16018215 | 0.81 | STIM1 (0.51) | STIM1ORAI1ORAI2KITBRAF | |
| SCHEMBL12155457 | 0.81 | STIM1 (0.60) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL14885666 | 0.81 | STIM1 (0.50) | STIM1ORAI1ORAI2NPC1RAB9A | |
| SCHEMBL12156210 | 0.81 | STIM1 (0.68) | STIM1ORAI1ORAI2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9856240-B2 | Compounds that modulate intracellular calcium | CALCIMEDICA, INC. (US) | 2018-01-02 | — | — | US | disclosed |
| US-20140256745-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | CALCIMEDICA, INC. (US) | 2014-09-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140256745-A1 | COMPOUNDS THAT MODULATE INTRACELLULAR CALCIUM | ORAI1, SARAF, RYR2 | STIM1 17/4885ORAI1 1/4885ORAI2 19/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.