Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 10/20 | 0.62 |
| ▸ | GSK3A | P49840 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 3/20 | 0.46 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | CDK7 | P50613 | 4/20 | 0.43 |
| ▸ | CCNH | P51946 | 4/20 | 0.43 |
| ▸ | MNAT1 | P51948 | 4/20 | 0.43 |
| ▸ | CCNK | O75909 | 3/20 | 0.43 |
| ▸ | CDK12 | Q9NYV4 | 3/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16022127 | 1.00 | MAPK6 (0.62) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| SCHEMBL16013085 | 0.90 | MAPK6 (0.62) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| SCHEMBL16012829 | 0.90 | MAPK6 (0.62) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| SCHEMBL16012828 | 0.90 | MAPK6 (0.62) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| SCHEMBL16022126 | 0.89 | MAPK6 (0.64) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| SCHEMBL18813107 | 0.89 | MAPK6 (0.64) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| SCHEMBL16022088 | 0.89 | MAPK6 (0.64) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| SCHEMBL16012197 | 0.88 | MAPK6 (0.60) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| SCHEMBL16012196 | 0.88 | MAPK6 (0.60) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 | |
| Formic Acid SCHEMBL16012727 | 0.88 | MAPK6 (0.59) | MAPK6GSK3AGSK3BEIF2AK4CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014135244-A1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2014-09-12 | — | — | WO | disclosed |