Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 12/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | EIF2AK4 | Q9P2K8 | 7/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18830258 | 0.89 | MAPK6 (0.66) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16012741 | 0.88 | MAPK6 (0.57) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL17435351 | 0.87 | MAPK6 (0.50) | MAPK6GSK3AGSK3BEIF2AK4 | |
| Carbamic Acid SCHEMBL18813127 | 0.85 | MAPK6 (0.51) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16012546 | 0.78 | MAPK6 (0.89) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18830294 | 0.78 | MAPK6 (0.89) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18830502 | 0.77 | MAPK6 (0.53) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16012360 | 0.76 | MAPK6 (0.68) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18830261 | 0.75 | MAPK6 (0.56) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16012897 | 0.74 | MAPK6 (0.70) | MAPK6GSK3AGSK3BEIF2AK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014135244-A1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2014-09-12 | — | — | WO | disclosed |