Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK6 | Q16659 | 13/20 | 0.60 |
| ▸ | GSK3A | P49840 | 2/20 | 0.45 |
| ▸ | GSK3B | P49841 | 2/20 | 0.45 |
| ▸ | EIF2AK4 | Q9P2K8 | 2/20 | 0.41 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.38 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17435308 | 0.84 | MAPK6 (0.65) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18830606 | 0.84 | MAPK6 (0.75) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18830313 | 0.83 | MAPK6 (0.57) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18830240 | 0.82 | MAPK6 (0.57) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL18813105 | 0.80 | MAPK6 (0.62) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16011890 | 0.80 | MAPK6 (0.73) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16012046 | 0.80 | MAPK6 (0.73) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16012291 | 0.80 | MAPK6 (0.73) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16014935 | 0.80 | MAPK6 (0.78) | MAPK6GSK3AGSK3BEIF2AK4 | |
| SCHEMBL16014920 | 0.80 | MAPK6 (0.56) | MAPK6GSK3AGSK3BEIF2AK4TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014135244-A1 | TRIAZOLO[4,5-D]PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF DISEASES SUCH AS CANCER | MERCK PATENT GMBH (DE) | 2014-09-12 | — | — | WO | disclosed |