Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 3/20 | 0.76 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.76 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.76 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.76 |
| ▸ | DEGS1 | O15121 | 1/20 | 0.76 |
| ▸ | NPC1 | O15118 | 3/20 | 0.65 |
| ▸ | RAB9A | P51151 | 3/20 | 0.65 |
| ▸ | NAMPT | P43490 | 1/20 | 0.60 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.57 |
| ▸ | GAA | P10253 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.56 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16705207 | 0.96 | HDAC8 (0.71) | HDAC8HDAC6HDAC3HDAC11DEGS1 | |
| SCHEMBL15214829 | 0.96 | HDAC8 (0.71) | HDAC8HDAC6HDAC3HDAC11DEGS1 | |
| SCHEMBL16021428 | 0.87 | HDAC3 (0.67) | HDAC8HDAC6HDAC3HDAC11DEGS1 | |
| SCHEMBL20284041 | 0.87 | DEGS1 (1.00) | HDAC8HDAC6HDAC3HDAC11DEGS1 | |
| SCHEMBL15214804 | 0.86 | HDAC8 (0.69) | HDAC8HDAC6HDAC3HDAC11DEGS1 | |
| SCHEMBL26154118 | 0.85 | HDAC8 (0.76) | HDAC8HDAC6HDAC3HDAC11DEGS1 | |
| SCHEMBL29536548 | 0.85 | — | — | |
| SCHEMBL1995773 | 0.85 | — | — | |
| SCHEMBL2565608 | 0.85 | HDAC8 (0.76) | HDAC8HDAC6HDAC3HDAC11DEGS1 | |
| Hydrochloric Acid SCHEMBL1996729 | 0.84 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2970326-B1 | SUBSTITUTED 5,6-RING-FUSED NAPHTHOPYRAN COMPOUNDS | TRANSITIONS OPTICAL INC (US) | 2017-11-29 | — | — | EP | disclosed |
| US-9029532-B2 | 5,6-ring-substituted naphthopyran compounds | TRANSITIONS OPTICAL, INC. (US) | 2015-05-12 | — | — | US | disclosed |
| US-20140256935-A1 | 5,6-RING-SUBSTITUTED NAPHTHOPYRAN COMPOUNDS | TRANSITIONS OPTICAL, INC. (US) | 2014-09-11 | — | — | US | disclosed |