Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 20/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16023129 | 0.85 | LRRK2 (0.75) | LRRK2 | |
| SCHEMBL16024804 | 0.82 | LRRK2 (0.79) | LRRK2 | |
| SCHEMBL16023150 | 0.78 | LRRK2 (0.78) | LRRK2 | |
| SCHEMBL16022625 | 0.78 | LRRK2 (0.77) | LRRK2 | |
| SCHEMBL19290961 | 0.74 | LRRK2 (0.81) | LRRK2 | |
| SCHEMBL16023019 | 0.74 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16022978 | 0.73 | LRRK2 (0.79) | LRRK2 | |
| SCHEMBL16022210 | 0.72 | LRRK2 (1.00) | LRRK2 | |
| SCHEMBL16525454 | 0.72 | LRRK2 (0.57) | LRRK2 | |
| SCHEMBL16022145 | 0.72 | LRRK2 (0.80) | LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014137719-A1 | COMPOUNDS INHIBITING LEUCINE-RICH REPEAT KINASE ENZYME ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2014-09-12 | — | — | WO | disclosed |