Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BACE1 | P56817 | 20/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13193804 | 0.82 | BACE1 (0.59) | BACE1BACE2KCNH2 | |
| SCHEMBL17169367 | 0.82 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL18636879 | 0.80 | BACE1 (0.50) | BACE1BACE2KCNH2 | |
| SCHEMBL10193244 | 0.79 | BACE1 (0.53) | BACE1BACE2KCNH2 | |
| SCHEMBL17169121 | 0.79 | BACE1 (0.48) | BACE1CYP2D6BACE2KCNH2 | |
| SCHEMBL15704711 | 0.78 | BACE1 (0.49) | BACE1CYP2D6BACE2KCNH2 | |
| SCHEMBL17169373 | 0.78 | BACE1 (0.49) | BACE1CYP2D6BACE2KCNH2 | |
| SCHEMBL16485640 | 0.77 | BACE1 (0.48) | BACE1BACE2 | |
| SCHEMBL10193209 | 0.77 | BACE1 (0.53) | BACE1BACE2KCNH2 | |
| SCHEMBL17340623 | 0.77 | NPC1 (0.70) | BACE1BACE2KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2014138484-A1 | PERFLUORINATED CYCLOPROPYL FUSED 1,3-OXAZIN-2-AMINE COMPOUNDS AS BETA-SECRETASE INHIBITORS AND METHODS OF USE | AMGEN INC. (US) | 2014-09-12 | — | — | WO | disclosed |