⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ampyzine SCHEMBL30627403 | 1.00 | — | — | |
| Ampyzine SCHEMBL160879 | 0.97 | POLB (0.53) | — | |
| Ampyzine SCHEMBL122178 | 0.87 | POLB (0.50) | — | |
| SCHEMBL13367380 | 0.84 | POLB (0.55) | — | |
| Ampyzine SCHEMBL27512340 | 0.82 | POLB (0.50) | — | |
| SCHEMBL18226427 | 0.80 | — | — | |
| SCHEMBL2223270 | 0.80 | — | — | |
| SCHEMBL1521276 | 0.78 | POLB (0.48) | — | |
| SCHEMBL10394905 | 0.77 | POLB (0.63) | — | |
| SCHEMBL18155168 | 0.75 | POLB (0.47) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 174 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250002475-A1 | PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS | EPICS THERAPEUTICS (BE) | 2025-01-02 | — | — | US | claimed |
| US-12091400-B2 | Piperidine derivatives as METTL3 inhibitors | EPICS THERAPEUTICS (BE) | 2024-09-17 | — | — | US | claimed |
| US-20240270716-A1 | PIPERIDINE DERIVATIVES AS METTL3 INHIBITORS | EPICS THERAPEUTICS (BE) | 2024-08-15 | — | — | US | claimed |
| CN-116836202-A | Tetrapyrazino-tri Azao-He-o derivative, preparation method and application thereof | 南方科技大学 | 2023-10-03 | — | — | CN | claimed |
| CN-114929345-A | Substituted pyrazole compounds as TOLL receptor inhibitors | 百时美施贵宝公司 | 2022-08-19 | — | — | CN | claimed |
| US-10772874-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. | 2020-09-15 | — | — | US | claimed |
| US-10456382-B2 | Compounds and compositions for the inhibition of NAMPT | FORMA TM, LLC (US) | 2019-10-29 | — | — | US | claimed |
| US-20190105307-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Valo Health, LLC | 2019-04-11 | — | — | US | claimed |
| US-20170368039-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA TM, LLC (US) | 2017-12-28 | — | — | US | claimed |
| US-20140294805-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | VALO EARLY DISCOVERY, INC. | 2014-10-02 | — | — | US | claimed |
| CN-102056927-B | Fused nitrogen containing heterocycles and compositions thereof as kinase inhibitors | IRM LLC | 2014-06-25 | — | — | CN | claimed |
| CN-103313989-A | Tricyclic PI3K inhibitor compounds and methods of use | HOFFMANN LA ROCHE | 2013-09-18 | — | — | CN | claimed |
| EP-2611804-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | Forma TM, LLC. (US) | 2013-07-10 | — | — | EP | claimed |
| CN-102260218-B | Synthesis method of aminopyrazine spice | BEIJING INST TECHNOLOGY | 2013-05-08 | — | — | CN | claimed |
| WO-2012031197-A1 | NOVEL COMPOUNDS AND COMPOSITIONS FOR THE INHIBITION OF NAMPT | FORMA THERAPEUTICS, INC. (US) | 2012-03-08 | — | — | WO | claimed |
| CN-102260218-A | Synthesis method of aminopyrazine spice | — | 2011-11-30 | — | — | CN | claimed |
| EP-1187244-A2 | Organic amines as additives for electrochemical cells | MERCK PATENT GmbH (DE) | 2002-03-13 | — | — | EP | claimed |
| US-12336981-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. (US) | 2025-06-24 | — | — | US | disclosed |
| US-4386210-A | CEPHALOSPORIN ANTIBIOTICS | ROUSSEL UCLAF (FR) | 1983-05-31 | — | — | US | disclosed |
| US-4288434-A | Cephalosporanic acid derivatives | ROUSSEL UCLAF (FR) | 1981-09-08 | — | — | US | disclosed |