⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21609593 | 1.00 | — | — | |
| SCHEMBL1345692 | 0.84 | — | — | |
| SCHEMBL1603583 | 0.78 | — | — | |
| SCHEMBL123271 | 0.74 | TSHR (0.35) | — | |
| SCHEMBL4209140 | 0.73 | — | — | |
| SCHEMBL1347204 | 0.73 | — | — | |
| SCHEMBL4163231 | 0.73 | — | — | |
| SCHEMBL27998298 | 0.72 | — | — | |
| SCHEMBL5751102 | 0.72 | — | — | |
| SCHEMBL9176570 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9809609-B2 | Water-soluble benzoazepine compound and its pharmaceutical composition | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2017-11-07 | — | — | US | disclosed |
| US-9303052-B2 | Water-soluble benzoazepine compound and its pharmaceutical composition | I. OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2016-04-05 | — | — | US | disclosed |
| EP-1968990-B1 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION | OTSUKA PHARMA CO LTD (JP) | 2015-02-11 | — | — | EP | disclosed |
| EP-2674436-A1 | Water-soluble benzoazepine compound and its pharmaceutical composition | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-12-18 | — | — | EP | disclosed |
| US-20130331358-A1 | Water-Soluble Benzoazepine Compound and Its Pharmaceutical Composition | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2013-12-12 | — | — | US | disclosed |
| US-20120277189-A1 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-11-01 | — | — | US | disclosed |
| US-20120277188-A1 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. | 2012-11-01 | — | — | US | disclosed |
| US-20110098250-A1 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. | 2011-04-28 | — | — | US | disclosed |
| US-20110082110-A1 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. | 2011-04-07 | — | — | US | disclosed |
| US-20100004206-A1 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2010-01-07 | — | — | US | disclosed |
| EP-1968990-A1 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION | Otsuka Pharmaceutical Co., Ltd. (JP) | 2008-09-17 | — | — | EP | disclosed |
| WO-2007074915-A1 | WATER-SOLUBLE BENZOAZEPINE COMPOUND AND ITS PHARMACEUTICAL COMPOSITION | OTSUKA PHARMACEUTICAL CO., LTD. (JP) | 2007-07-05 | — | — | WO | disclosed |
| EP-1706410-A2 | PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD (JP) | 2006-10-04 | — | — | EP | disclosed |
| WO-2005066142-A2 | PYRROLOPYRIMIDINE AND PYRROLOTRIAZINE DERIVATIVES AS CRF RECEPTOR ANTAGONISTS | TAISHO PHARMACEUTICAL CO., LTD. (JP) | 2005-07-21 | — | — | WO | disclosed |