Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCL2 | P10415 | 20/20 | 0.75 |
| ▸ | BCL2L1 | Q07817 | 8/20 | 0.73 |
| ▸ | NSD2 | O96028 | 1/20 | 0.73 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.73 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.73 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.73 |
| ▸ | BID | P55957 | 1/20 | 0.73 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.73 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.73 |
| ▸ | ASPH | Q12797 | 1/20 | 0.73 |
| ▸ | BCL2L2 | Q92843 | 1/20 | 0.73 |
| ▸ | BAD | Q92934 | 1/20 | 0.73 |
| ▸ | NSD1 | Q96L73 | 1/20 | 0.73 |
| ▸ | NSD3 | Q9BZ95 | 1/20 | 0.73 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16038586 | 0.96 | BCL2 (0.77) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL15991888 | 0.94 | BCL2 (0.82) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL16039278 | 0.92 | BCL2 (0.75) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL16037936 | 0.92 | BCL2 (0.75) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL16038819 | 0.91 | BCL2 (0.89) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL1701880 | 0.90 | BCL2 (0.78) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL28621835 | 0.89 | BCL2 (0.81) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL1702213 | 0.89 | BCL2 (0.81) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL1701830 | 0.89 | BCL2 (0.76) | BCL2BCL2L1NSD2ADORA3CYP2C9 | |
| SCHEMBL1808763 | 0.88 | BCL2 (0.81) | BCL2BCL2L1NSD2ADORA3CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210403467-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC (US) | 2021-12-30 | — | — | US | disclosed |
| CN-107987075-B | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | 艾伯维公司 | 2020-12-01 | — | — | CN | disclosed |
| US-20200331907-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC (US) | 2020-10-22 | — | — | US | disclosed |
| EP-3415514-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | AbbVie Inc. (US) | 2018-12-19 | — | — | EP | disclosed |
| US-20180354952-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC. | 2018-12-13 | — | — | US | disclosed |
| US-10081628-B2 | Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases | ABBVIE INC. (US) | 2018-09-25 | — | — | US | disclosed |
| EP-2970257-B1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC (US) | 2018-05-30 | — | — | EP | disclosed |
| US-20170008891-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC. | 2017-01-12 | — | — | US | disclosed |
| EP-2970257-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | AbbVie Inc. (US) | 2016-01-20 | — | — | EP | disclosed |
| US-20150299197-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC. | 2015-10-22 | — | — | US | disclosed |
| WO-2014158528-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC. (US) | 2014-10-02 | — | — | WO | disclosed |
| US-20140275082-A1 | APOPTOSIS-INDUCING AGENTS FOR THE TREATMENT OF CANCER AND IMMUNE AND AUTOIMMUNE DISEASES | ABBVIE INC. | 2014-09-18 | — | — | US | disclosed |